Not known Facts About phenobarbital sodium injection dailymed
Not known Facts About phenobarbital sodium injection dailymed
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Drug interactions: Most experiences of clinically significant drug interactions happening with the barbiturates have involved phenobarbital.
Contraindicated (1)pentobarbital will lessen the level or effect of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Contraindicated (1)pentobarbital will minimize the level or effect of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the level or effect of eletriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will reduce the level or effect of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Potent CYP3A4 inducers may decrease midostaurin concentrations causing lessened efficacy.
pentobarbital will lessen the level or effect of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to the minimize in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, advancement of a withdrawal syndrome in a patient who's got formulated Bodily dependence to fentanyl.
pentobarbital will decrease the level or effect of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
Observe Intently (1)pentobarbital will lower the level or pentobarbital sodium injection uses effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the extent or effect of zaleplon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unidentified.
The DOJ wouldn't touch upon where the pentobarbital it designs to utilize in executions will come from, or how it will be administered.
pentobarbital will reduce the level or effect of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.
Watch Closely (one)pentobarbital will reduce the level or effect of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to a lower in fentanyl plasma concentrations, lack of efficacy or, perhaps, progress of the withdrawal syndrome in the patient that has made Actual physical dependence to fentanyl. Just after halting a CYP3A4 inducer, since the effects on the inducer decrease, the fentanyl plasma concentration will improve which could maximize or lengthen the two the therapeutic and adverse effects.
pentobarbital will lower the level or effect of tolterodine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (name previously used: bishydroxycoumarin) and causes a minimize in anticoagulant exercise as measured because of the prothrombin time. Barbiturates can induce hepatic microsomal enzymes resulting in greater metabolism and lessened anticoagulant response of oral anticoagulants (e.